Babble Connect | Fertility Knowledge Hub

Fertility Tests & Investigations A–Z

Your fertility journey, better informed. Understand your options, explore common tests and discover when specialist advice may help.

Understanding fertility testing

If you're trying to conceive, preparing for fertility treatment, considering egg or sperm freezing, or simply looking to understand your reproductive health, fertility testing can help answer important questions.

Some tests assess hormones and ovulation. Others investigate sperm health, the uterus, fallopian tubes or inherited genetic conditions.

But fertility testing isn't one-size-fits-all. Not everyone needs every test, and some commonly advertised investigations have limited evidence or are only appropriate in specific circumstances.

In-depth test guides

Fertility tests by journey

A–Z fertility testing directory

A

Estimates ovarian reserve and likely ovarian response to stimulation

When used: IVF planning, ovarian reserve assessment

Counts small ovarian follicles using ultrasound

When used: IVF planning, ovarian reserve assessment

Antiphospholipid Antibody Tests

Investigates antiphospholipid syndrome, a possible cause of pregnancy complications

When used: Selected recurrent pregnancy loss investigations

B

Assesses reproductive hormone patterns, usually early in the menstrual cycle

When used: Selected ovarian function investigations

C

Chlamydia Screening

Detects an infection that can damage fallopian tubes

When used: Preconception care, infertility investigations

Chromosome / Karyotype Testing

Identifies certain chromosome abnormalities

When used: Selected infertility or recurrent miscarriage cases

Checks carrier status for variants associated with cystic fibrosis

When used: Preconception or donor screening

D

Assesses sperm DNA damage

When used: Selected specialist male fertility investigations

E

Endometrial Biopsy

Samples uterine lining tissue to investigate specific suspected conditions

When used: Selected uterine investigations

Specialist ultrasound, MRI or laparoscopy to look for endometriosis

When used: Painful periods, pelvic pain or unexplained infertility

Measures an important reproductive hormone

When used: Cycle assessment and ovarian stimulation monitoring

F

Assesses whether fallopian tubes appear open

When used: Investigation of possible tubal infertility

Evaluates selected reproductive hormones

When used: Irregular cycles, suspected hormonal disorders

G

Identifies inherited variants relevant to future children

When used: Preconception planning, donor conception

H

X-ray investigation of uterine cavity and fallopian tube patency

When used: Tubal infertility investigations

Ultrasound-based assessment of fallopian tube patency

When used: Tubal investigations

Hysteroscopy

Examines the uterine cavity using a small camera

When used: Suspected polyps, fibroids, adhesions or uterine abnormalities

I

Infectious Disease Screening

Tests for infections such as HIV, hepatitis B and hepatitis C

When used: Before assisted reproduction, donation or according to risk

K

Karyotype Analysis

Assesses chromosome number and structure

When used: Selected genetic fertility investigations

L

Surgical examination of pelvic organs

When used: Selected cases of suspected endometriosis or pelvic pathology

LH Testing

Detects luteinising hormone surges associated with ovulation

When used: Ovulation tracking

O

Combines markers such as AMH and AFC

When used: Fertility treatment planning

Helps establish whether ovulation has occurred

When used: Irregular cycles or suspected ovulatory problems

P

Pelvic Ultrasound

Examines the uterus and ovaries

When used: Structural and ovarian assessments

Screens IVF embryos for chromosome copy-number abnormalities

When used: IVF add-on; benefits and limitations require individual discussion

PGT-M

Tests IVF embryos for a specified inherited monogenic condition

When used: Selected IVF cases with known genetic risk

PGT-SR

Tests IVF embryos for chromosome imbalances linked to parental structural rearrangements

When used: Selected IVF cases

Measures a hormone that can interfere with ovulation when elevated

When used: Menstrual irregularity or suspected hormonal problems

R

Recurrent Pregnancy Loss Investigations

Targeted assessment of possible contributing factors

When used: After repeated pregnancy losses, according to clinical guidelines

S

Saline Infusion Sonography (SIS)

Uses saline and ultrasound to assess the uterine cavity

When used: Suspected polyps, fibroids or cavity abnormalities

Evaluates sperm concentration, motility, morphology and semen volume

When used: First-line male fertility investigation

T

Assesses hormonal causes of impaired sperm production

When used: Abnormal semen analysis or relevant symptoms

Investigates thyroid dysfunction that may affect reproductive health

When used: Selected infertility, menstrual or pregnancy-related assessments

Transvaginal Ultrasound

Detailed imaging of reproductive anatomy

When used: Ovarian, uterine and fertility assessments

V

Varicocele Examination

Checks for enlarged veins around the testicle

When used: Male infertility evaluation

Y

Y-Chromosome Microdeletion

Investigates certain genetic causes of severely impaired sperm production

When used: Selected severe oligospermia or azoospermia cases

Specialist tests and IVF add-ons

Some investigations are offered during IVF as optional extras. Many have limited evidence that they improve the chance of having a baby. Ask what difference a result would make before paying.

Review the independent evidence first: HFEA Treatment Add-ons guidance

ERA / Endometrial Receptivity Testing

Attempts to identify an individualised embryo transfer window. Evidence does not support routine use for improving live birth rates.

Endometrial Microbiome Testing (EMMA)

Analyses bacteria in the uterine environment. Clinical usefulness for improving IVF outcomes remains unproven.

Chronic Endometritis Testing

May involve endometrial biopsy and tissue assessment where chronic inflammation of the uterine lining is suspected.

NK Cell Testing

Measures natural killer cells in blood or endometrial tissue. Routine testing is not supported for infertility or recurrent pregnancy loss.

Reproductive Immunology Panels

Broad immune testing is sometimes marketed for IVF failure or miscarriage, but many panels lack validated clinical utility.

Thrombophilia Testing

Selected testing may be appropriate based on personal history or specific conditions. Broad inherited thrombophilia screening is not routinely recommended for recurrent miscarriage alone.

Sperm Oxidative Stress Testing

Investigates oxidative stress associated with sperm damage; routine clinical usefulness remains uncertain.

Sperm Selection Tests

Techniques intended to help select sperm for assisted reproduction; evidence varies by method.

Adenomyosis Assessment

Usually involves transvaginal ultrasound, sometimes MRI, when symptoms or fertility history suggest adenomyosis.

Non-Invasive Prenatal Testing (NIPT)

A screening blood test during pregnancy for selected chromosomal conditions; not a diagnostic test and not an infertility investigation.

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Last reviewed: October 2026 by the Babble Connect editorial team.

This information is for general education only and is not medical advice. Not everyone needs every test, and no single test can determine your fertility. Please discuss your individual results and options with a qualified fertility specialist.

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© 2026 Babble Connect

Your Fertility Guide

© 2026 Babble Connect

Your Fertility Guide

© 2026 Babble Connect